Infographic: How to Make an Artificial Stem Cell

See researchers' recipe for synthetic mesenchymal stem cells, which showed cardiac regenerative potential in mice.

Diana Kwon
Diana Kwon

Diana is a freelance science journalist who covers the life sciences, health, and academic life. She’s a regular contributor to The Scientist and her work has appeared in several other...

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May 31, 2017

© GEORGE RETSECK. Redrawn from Circ Res, doi:10.1161/CIRCRESAHA.116.310374, 2017, with permission

Stem "Cell" Synthesis

To create synthetic mesenchymal stem cells (synMSCs), the researchers start with human bone marrow-derived MSCs (1). They combine secretions from these cells with a biodegradable polymer, poly(lactic-co-glycolic acid) or?PLGA, creating microparticles (2). The microparticles are then encased in cell membranes derived from human MSCs (3) to allow the synMSCs to anchor to tissues and gradually release secreted factors, mimicking real MSCs (4).

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Infographic: How to Make an Artificial Stem Cell

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