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Infographic: How to Make an Artificial Stem Cell

See researchers' recipe for synthetic mesenchymal stem cells, which showed cardiac regenerative potential in mice.

May 31, 2017
Diana Kwon

© GEORGE RETSECK. Redrawn from Circ Res, doi:10.1161/CIRCRESAHA.116.310374, 2017, with permission

Stem "Cell" Synthesis

To create synthetic mesenchymal stem cells (synMSCs), the researchers start with human bone marrow-derived MSCs (1). They combine secretions from these cells with a biodegradable polymer, poly(lactic-co-glycolic acid) or?PLGA, creating microparticles (2). The microparticles are then encased in cell membranes derived from human MSCs (3) to allow the synMSCs to anchor to tissues and gradually release secreted factors, mimicking real MSCs (4).

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