Menu

Infographic: Targeting Cancer Antigens

Neoantigens may serve as valuable targets for new immunotherapies.

Mar 31, 2017
Stephen P. Schoenberger and Ezra Cohen

As tumor cells divide, they accrue mutations that result in modified or novel peptide sequences that are unique to the cancer. Known as neoantigens, these tumor-specific proteins could be the key to developing effective cancer therapies.

Cancer typically develops from a single cell that, as it divides into a clonal population, accumulates function-altering mutations in the genes that control cell growth, survival, and differentiation. Missense mutations, frameshifts, translocations, and mRNA splicing variants, as well as mutations that influence posttranslational processing such as phosphorylation and glycosylation, can all lead to molecular changes that can be recognized by the T cells tasked with detecting foreign peptides.

Receptors on the surface of cytotoxic T cells recognize peptides presented by major histocompatibility complex (MHC) molecules on the tumor cell membrane. CD8 acts as a T-cell co-receptor that facilitates antigen recognition. MHC-bound peptides that differ in sequence—even by a single amino acid—can be bound by appropriate T-cell receptors and targeted for destruction.

THE SCIENTIST STAFF

July 2019

On Target

Researchers strive to make individualized medicine a reality

Marketplace

Sponsored Product Updates

IDT and Washington University join forces to increase access to the latest NGS technologies
IDT and Washington University join forces to increase access to the latest NGS technologies
As part of its commitment to advocate for the genomics age, Integrated DNA Technologies (IDT) aims to lower the barriers to access the latest NGS technologies.
Bio-Rad Launches Bio-Plex Pro Human Immunotherapy Panel 20-plex Multiplex Assay, a targeted tool for researching signaling networks in Immunotherapy Research
Bio-Rad Launches Bio-Plex Pro Human Immunotherapy Panel 20-plex Multiplex Assay, a targeted tool for researching signaling networks in Immunotherapy Research
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) July 15, 2019 announced the launch of its Bio-Plex Pro Human Immunotherapy Panel 20-plex, a multiplex immunoassay that offers a targeted approach for Immunotherapy Research.
DeNovoMAX - NRGene's new genomics tool to meet a major agbio need:
DeNovoMAX - NRGene's new genomics tool to meet a major agbio need:
NRGene has launched a new product that aims to empower breeding and maximize agricultural yield as part of the Denovo assembly product suite offered by the company.
Overcoming the Efficiency Challenge in Clinical NGS
Overcoming the Efficiency Challenge in Clinical NGS
Download this white paper to see how an ECS lab serving a network of more than 10,000 healthcare providers integrated QIAGEN Clinical Insight (QCI) Interpret to significantly reduce manual variant curation efforts and increase workflow efficiency by 80%!