Menu

Infographic: Tumor-Associated Macrophages and Cancer

The immune cells play various roles in the tumor—some that assist cancer's spread, and others that hinder it.

Mar 31, 2018
Amanda B. Keener

T

umors use chemokine signals to draw monocytes and tissue-resident macrophages into the tumor microenvironment, where the cells become tumor-associated macrophages (TAMs). Once believed to be wholly supportive of cancerous growth, these cells also play important roles in protecting against disease.

Tumor-assisting macrophages: The M2 phenotype

TAMs can take on a variety of roles to support cancer cell survival and dissemination. Originating either from monocytes that come from bone marrow, or tissue-resident macrophages that arise during embryonic development, they can repress antitumor immunity by secreting cytokines such as IL-10, which blocks dendritic cell activation, and TGF-β, which blunts T-cell responses (1). A specific subset of TAMs that produce a protein called Tie2 can also stimulate angiogenesis through secretion of vascular endothelial growth factor (VEGF) and other molecules (2). At the same time, Tie2+ macrophages come together with cancer cells and blood vessel endothelial cells to form complexes, called tumor microenvironments of metastasis (TMEMs), that create openings in blood vessels (3). Macrophages at distant sites then help cancer cells exit blood vessels and seed new tumors (4).

© SCOTT LEIGHTON

 

Tumor-killing macrophages: The M1 phenotype

TAMs have the potential to aid antitumor immune responses by presenting cancer cell antigens to T cells and producing cytokines that activate dendritic cells and T cells (1). Macrophages are also experts at phagocytosing and degrading foreign cells, including cancer cells (2).

 
 
© SCOTT LEIGHTON

Read the full story.

November 2018

Intelligent Science

Wrapping our heads around human smarts

Marketplace

Sponsored Product Updates

Complete Pathology Solutions: Make Every Minute Count

Complete Pathology Solutions: Make Every Minute Count

From sample collection and handling, to fixation and processing, tissue staining, and covering all your IHC and water purification needs—you can have confidence in the quality of your results with MilliporeSigma's one-stop pathology solution.

Preparing Cell Or Tissue Lysates For ELISA Kits

Preparing Cell Or Tissue Lysates For ELISA Kits

RayBiotech manufactures over 2,000 high fully validated, GMP-compliant ELISA kits. In this blog post we explain how to prepare cell or tissue lysates for ELISA Kits.

Norgen Biotek Achieves Illumina Propel Certification as a Service Provider for Next Generation Sequencing

Norgen Biotek Achieves Illumina Propel Certification as a Service Provider for Next Generation Sequencing

Norgen Biotek Corp., an innovative privately held Canadian biotechnology company focusing primarily on nucleic acid and protein stabilization and purification, as well as providing high quality services to the scientific community, today announced that it has become Propel-Certified through Illumina as a Next Generation Sequencing (NGS) service provider.

Slice® Safety Cutters for Lab Work

Slice® Safety Cutters for Lab Work

Slice cutting tools—which feature our patent-pending safety blades—meet many lab-specific requirements. Our scalpels and craft knives are well suited for delicate work, and our utility knives are good for general use.