Nailing Down HAR Function

A remaining challenge in the study of human accelerated regions (HARs) is establishing their specific functions during development and other biological processes.

Jul 31, 2016
Katherine S. Pollard

Modern stem cell technologies could provide one way to sttudy human accelerated regions (HARs). Using precision gene editors to change the DNA in a chimp cell to match the sequence of a human HAR, for example, researchers can isolate the effects of that HAR. 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Take skin biopsy from a nonhuman primate.

 

 

 

 

 

 

 

 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Reprogram skin fibroblasts into brain, heart, or liver cells.

 

 

 

 

 

 

 

 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Edit the DNA of a specific chimp HAR to match the human sequence.

 

 

 

 

 

 

 

 

© NOVIE STUDIO, 2016, ALL RIGHTS RESERVED

Test the cells for differences in gene expression.

 

 

 

 

 

 

 

 

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