These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

J.F. Roeth et al., "HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail." J Cell Biol, 167:903–13, Dec. 6, 2004.

This study defines a novel pathway by which immune evasion protein Nef of HIV-1 traffics MHC-I proteins in T cells from the trans-Golgi network (TGN) to the lysosome for degradation. Indeed, the authors show that Nef accomplishes this by stabilizing a physical association between MHC-I and adaptor protein AP-1, a cellular protein complex implicated in TGN to endolysosomal pathways.

- Ted HansenWashington University School of Medicine, St. Louis

D.E. Martin et al., "TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1," Cell, 119:969–79, Dec. 29, 2004.

Regulation of ribosomal biosynthesis in response to environmental cues is demonstrated here to...

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