These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

D.D. Sarbassov et al., "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton," Curr Biol, 14:1296–302, July 27, 2004.

The authors describe a novel molecular mechanism whereby downstream signaling in the mammalian target of the rapamycin (mTOR) pathway may proceed in a rapamycin-insensitive manner. This may help explain several recent reports of rapamycin-resistant effects resulting from cellular mTOR activation and also has implications for the design of drugs targeting the mTOR pathway.

- Peter Taylor

University of Dundee, UK

N. Ramachandran et al., "Self-assembling protein microarrays," Science, 305:86–90, July 2, 2004.

Protein microarrays were generated by printing cDNAs onto glass slides, translating target proteins with mammalian reticulocyte lysate, and using epitope tags fused to the proteins to immobilize them in situ....

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