These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

Q.L. Ying et al., "BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3," Cell, 115:281–92, Oct. 31, 2003.

Embryonic stem (ES) cells can be derived and propagated in the presence of bone morphogenetic protein 4 (BMP4) and leukemia inhibitory factor (LIF) without serum or feeder cells. BMP4 induces expression of inhibitor of differentiation (Id) genes in ES cells via the Smad pathway, which, in conjunction with LIF/STAT3 pathway, is able to sustain self-renewal of stem cells while preventing their differentiation.

- Azim Surani

The Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology

B. Kuhlman et al., "Design of a novel globular protein fold with atomic level accuracy," Science, 302:1364–8, Nov. 21, 2003.

A protein is designed...

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