This webinar will be hosted live and available on-demand.
Wednesday, July 15th, 2026
11:00 AM - 12:30 PM ET
Functional genomics and CRISPR perturbation screens have become important tools for investigating gene function and identifying disease-relevant biology. While transcriptomic profiling provides valuable insight into cellular responses to genetic perturbations, RNA measurements alone may not fully capture downstream biological processes such as protein activation, secretion, and post-translational regulation. Integrating protein-level measurements with transcriptomic analysis can provide a more comprehensive view of cellular phenotypes and molecular mechanisms.
In this webinar, brought to you by Nomic Bio, Amanda McQuade, postdoctoral scholar at the University of California, San Francisco, and Nathaniel Robichaud, partnerships lead at Nomic Bio, will discuss how integrated proteomic profiling can complement transcriptomic analysis in CRISPR screening workflows. The session will examine the use of CRISPR interference (CRISPRi) screening to identify transcriptional and epigenetic regulators of disease-associated microglial activation states, as well as approaches to characterize cellular phenotypes detectable primarily by protein-level measurements. The discussion will also highlight how combined transcriptomic and proteomic datasets support target validation and prioritization in discovery biology research.
Topics to be covered
- Integrating proteomic and transcriptomic profiling in CRISPR screening workflows
- Protein-level responses to genetic perturbations
- CRISPRi approaches for studying microglial activation states
- Identification of transcriptional and epigenetic regulators of neuroinflammatory biology
- Cellular phenotypes detectable through proteomic profiling
- Multi-omics approaches for target validation and prioritization
 | Amanda McQuade, PhD |
 | Nathaniel Robichaud, PhD |
