The liver is the primary organ involved in heme detoxification under disease conditions, but its self-protective mechanisms against toxic compounds are unknown. In the April Gastroenterology Takanori Kyokane and colleagues from Nagoya University School of Medicine, Nagoya, suggest that carbon monoxide (CO), the gaseous product of heme oxygenase (HO), may have a protective role against hepatobiliary dysfunction caused by heme overloading under sepsis and stress conditions.Kyokane et al perfused l
The liver is the primary organ involved in heme detoxification under disease conditions, but its self-protective mechanisms against toxic compounds are unknown. In the April
Kyokane
In addition, CO supplementation attenuated the vasoconstriction and cholestasis caused by coadministration of aminoguanidine (an NO synthase inhibitor) and zinc protoporphyrin-IX (an HO inhibitor). This suggests that CO is hepatoprotective and that simultaneous elimination of NO and ...
The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.
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