The liver is the primary organ involved in heme detoxification under disease conditions, but its self-protective mechanisms against toxic compounds are unknown. In the April Gastroenterology Takanori Kyokane and colleagues from Nagoya University School of Medicine, Nagoya, suggest that carbon monoxide (CO), the gaseous product of heme oxygenase (HO), may have a protective role against hepatobiliary dysfunction caused by heme overloading under sepsis and stress conditions.Kyokane et al perfused l
The liver is the primary organ involved in heme detoxification under disease conditions, but its self-protective mechanisms against toxic compounds are unknown. In the April
Kyokane
In addition, CO supplementation attenuated the vasoconstriction and cholestasis caused by coadministration of aminoguanidine (an NO synthase inhibitor) and zinc protoporphyrin-IX (an HO inhibitor). This suggests that CO is hepatoprotective and that simultaneous elimination of NO and ...
A citizen science game explores how social choices and networks can influence how an illness moves through a population.
View this Issue
Learn how a next-generation platform accelerates biological research by enabling high-throughput, spatially resolved multiomics profiling.
In this webinar, Imogen Binnian will share how AI and gene synthesis technology can accelerate the discovery and validation of novel disease traits.
Real-time imaging enhances fluorescence activated cell sorting (FACS) to help scientists overcome the cost and burden of validation.
New innovations provide scientists with easy access to robust and accurate control samples for quality control applications.
Setting new standards for intelligent mass detection, sensitivity, and sustainability.
The Wellcome Sanger Institute, Helmholtz Munich, and Parse Biosciences have announced a landmark international collaboration to create a Cancer Plasticity Atlas.
Multi-center project will profile over 40,000 samples using ultra-sensitive NULISA™ technology.
Discover how Alderley Analytical meet regulatory demands and high-throughput challenges—processing 10,000+ dirty samples with consistent performance of the Xevo TQ Absolute XR Mass Spectrometer.
