(The Scientist, Vol:10 #6, p.8, March 18, 1996)
MARK I. GREENE, John Eckman Professor of Medical Science, University of Pennsylvania, Philadelphia
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Mark Greene has been at the forefront of the fast-growing field of immunobiology and receptor research for the past 15 years. At the University of Pennsylvania's Cancer Center, Greene is currently working to define the principles by which certain receptor families, including the neu and EGF receptors, operate in causing cell growth and malignancy. Innovations unavailable 15 years ago have made possible recent gains in understanding receptor behavior. As an outgrowth of his research, Greene is using new immunologic techniques to design molecules that can turn receptors on and off, thereby preventing tumor development. He says: "We have made extraordinary, unexpected progress. What has helped us greatly is the...