Mina Bissell

The Scientist Date: July 22, 1996 THE SCIENTIST® The Newspaper for the Life Sciences Professional "Science is inseparable from other issues that confront us in our daily lives, and THE SCIENTIST presents both sides of controversial issues thoroughly....THE SCIENTIST tells our stories." Mina Bissell, director, Life Sciences Division, Berkeley National Laboratory; president-elect, American Society for Cell Biology, Washington, D.C. From the outset of her career as a scientist, Mina Bissell

The Scientist Staff
Jul 21, 1996

The Scientist

Date: July 22, 1996


THE SCIENTIST®

The Newspaper for the Life Sciences Professional
"Science is inseparable from other issues that confront us in our daily lives, and THE SCIENTIST presents both sides of controversial issues thoroughly....THE SCIENTIST tells our stories."

Mina Bissell, director, Life Sciences Division, Berkeley National Laboratory; president-elect, American Society for Cell Biology, Washington, D.C.

From the outset of her career as a scientist, Mina Bissell has been an iconoclast. For the past 25 years, she has been engaged in understanding how a normal cell remains normal in order to comprehend how a cell becomes malignant. In 1981, based on her work with cultured cells, Bissell developed the concept that the differentiated state of normal cells is unstable. In 1982, she proposed a model of "dynamic reciprocity," which argued that the microenvironment-and specifically the extracellular matrix (ECM)-has crucial information for functional differentiation. In the last...

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