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A Cutting Edge Reply

A recent article 1 emphasized the increasing obesity within the American population, and the author criticized the Food and Drug Administration for not allowing wider use of olestra to reduce fat/caloric intake. This article crystallizes what is wrong with much health-related research today. It is a classic example of looking for a 'magic bullet' approach to a serious problem rather than making the comprehensive lifestyle changes required. I have been conducting a text-mining study on the disc

Ronald Kostoff
A recent article 1 emphasized the increasing obesity within the American population, and the author criticized the Food and Drug Administration for not allowing wider use of olestra to reduce fat/caloric intake. This article crystallizes what is wrong with much health-related research today. It is a classic example of looking for a 'magic bullet' approach to a serious problem rather than making the comprehensive lifestyle changes required.

I have been conducting a text-mining study on the discipline of caloric restriction, focusing on the eclectic laboratory and clinical nonpathological experiences with controlled caloric restriction for health improvement, applied to all living species. Excluded are starvation, disease-caused caloric restriction, surgically-driven caloric restriction, and psychologically-driven caloric restriction (bulimia, anorexia). Preliminary results offer the following conclusions:

  • Caloric restriction in species with short life spans, mainly rodents, increases mean and maximal life-span substantially. 2-6 In parallel, some of these studies show how the degenerative diseases...

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