Gum Disease

Gregory Smutzer's article, "Molecular Demolition,"1 does not mention perhaps the most common disease attributed to the actions of matrix metalloproteinases (MMPs): chronic periodontitis, better known as "gum disease."2 In periodontitis, MMP-8 is released by degranulating polymorphonuclear neutrophils, and is also secreted by fibroblasts, endothelial cells, epithelial cells and plasma cells in and around the gingival sulcus.3 Adult tooth loss from periodontitis is not usually life-threatening, bu

Thomas Reinhart
Apr 28, 2002
Gregory Smutzer's article, "Molecular Demolition,"1 does not mention perhaps the most common disease attributed to the actions of matrix metalloproteinases (MMPs): chronic periodontitis, better known as "gum disease."2 In periodontitis, MMP-8 is released by degranulating polymorphonuclear neutrophils, and is also secreted by fibroblasts, endothelial cells, epithelial cells and plasma cells in and around the gingival sulcus.3 Adult tooth loss from periodontitis is not usually life-threatening, but how many of us want to be without a well-functioning natural dentition?
Thomas C. Reinhart, DDS
University Medical Park
4450 E. Fletcher Ave. - Suite B
Tampa FL 33613

References
1. G. Smutzer, "Molecular demolition," The Scientist, 16[4]:34, Feb. 18, 2002.

2. H. Birkedal-Hansen et al., "Role of matrix metalloproteinases in human periodontal disease," Journal of Periodontology, 64:474-84, 1993.

3. N. Buduneli et al, "Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase...

Interested in reading more?

The Scientist ARCHIVED CONTENT

ACCESS MORE THAN 30,000 ARTICLES ACROSS MANY TOPICS AND DISCIPLINES

Become a Member of

Receive full access to more than 35 years of archived stories, digital editions of The Scientist Magazine, and much more!
Already a member?