Mechanisms of HIV Infection

Mechanisms of HIV Infection Regarding your article, "Researchers Dissect the Mechanisms of HIV Infection,"1 in my opinion, DC-SIGN researchers have neglected an important means of HIV-1 and dendrite attachment important to the HIV-1 infection process. As HIV-1 buds from the host cell of replication membrane during its budding maturation process, many different host cell molecules are incorporated into the HIV-1 viral envelope. Among these budding acquired molecules (BAMs) are functional ICA

Jesse Creel
Feb 23, 2003

Mechanisms of HIV Infection


Regarding your article, "Researchers Dissect the Mechanisms of HIV Infection,"1 in my opinion, DC-SIGN researchers have neglected an important means of HIV-1 and dendrite attachment important to the HIV-1 infection process. As HIV-1 buds from the host cell of replication membrane during its budding maturation process, many different host cell molecules are incorporated into the HIV-1 viral envelope. Among these budding acquired molecules (BAMs) are functional ICAM-2 and ICAM-3, DC-SIGN's natural ligands, per your article. Once incorporated into HIV-1's viral envelope, these ICAM-2 and ICAM-3 (BAMs) could serve to attach HIV-1 to dendrites via binding/attachment interactions with DC-SIGN present on the dendrite cellular membrane, thereby facilitating in trans HIV-1 infection of T cells akin to what is suggested for HIV-1 gp120 and DC-SIGN interactions.

A better understanding of this and other BAMs actions are very important to the design of a therapeutic and preventive HIV-1...

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