Lots of splicing regulators

Researchers nearly triple number of known alternative regulators in Drosophila

| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

Researchers report in the online edition of PNAS this week that they have discovered nearly 30 alternative splicing regulators in Drosophila—nearly triple the number previously known—using a novel RNA interference (RNAi) screen.

"Most people in the splicing regulation field, including myself, have thought that splicing is regulated by RNA binding proteins that are not components of the spliceosome and that they do so by binding to the RNA where they either enhance or prevent the spliceosome from recognizing the regulated exon. The implications of our findings are that alternative splicing does not need to be regulated by these auxiliary proteins," author Brenton Graveley at the University of Connecticut Health Center in Farmington told The Scientist. "This does not mean that splicing is not regulated by auxiliary splicing factors, but rather seems to be a previously unrealized mechanism by which splicing can be regulated."

Alternative splicing, which generates multiple mRNAs from ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Meet the Author

  • Charles Choi

    This person does not yet have a bio.
Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo
New Frontiers in Vaccine Development

New Frontiers in Vaccine Development

Sino

Products

Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio
Inventia Life Science

Inventia Life Science Launches RASTRUM™ Allegro to Revolutionize High-Throughput 3D Cell Culture for Drug Discovery and Disease Research

An illustration of differently shaped viruses.

Detecting Novel Viruses Using a Comprehensive Enrichment Panel

Twist Bio