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Unwound DNA being transcribed into mRNA
Starting Strong for Successful mRNA Therapeutic Development 
Standardized and scalable in vitro transcription reagents allow researchers to enhance and accelerate cell-free mRNA synthesis.
Starting Strong for Successful mRNA Therapeutic Development 
Starting Strong for Successful mRNA Therapeutic Development 

Standardized and scalable in vitro transcription reagents allow researchers to enhance and accelerate cell-free mRNA synthesis.

Standardized and scalable in vitro transcription reagents allow researchers to enhance and accelerate cell-free mRNA synthesis.

Magazine Issue

A baby rhesus macaque against a forest backdrop.
White Blood Cells, Hurricanes, and the Monkeys of Cayo Santiago
Hannah Thomasy, PhD | Oct 1, 2024 | 2 min read
Citizen scientists help monitor monkey immune cells, providing a foundation for future work on stress, sociality, and aging.
Cartoon of a cell with blue chromosomes and gold telomeres. One chromosome is zoomed in in a callout, and gold DNA is extending out of the telomere. 
Going to New Lengths to Measure Chromosome Ends
Shelby Bradford, PhD and Priyom Bose, PhD | Oct 1, 2024 | 2 min read
A novel sequencing-based method revealed chromosome-specific telomere lengths, challenging prior models.
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Why Do People Have Different Blood Types?
Hannah Thomasy, PhD | Oct 1, 2024 | 2 min read
Humanity’s microscopic foes may be to blame for the ABO polymorphism.
Medicinal test
Best Pipetting Practices
The Scientist Staff | Oct 1, 2024 | 2 min read
Correct pipetting techniques allow scientists to instantly improve experimental accuracy.
A cross section of the pistil of <em >Arabidopsis thaliana&nbsp;</em>plant. Pollen grains are labeled with fluorescent markers and sit at the top of the structure. Fluorescently tagged pollen tubes penetrate the plant&rsquo;s ovary where the ovules (small, curved structures) are located.
The Hidden Dance of Plant Fertilization
Mariella Bodemeier Loayza Careaga, PhD | Oct 1, 2024 | 2 min read
A new method enables clear visualization of the dynamic changes during angiosperm reproduction.
Cartoon of three people helping each other climb up stairs.&nbsp;
How Can Researchers Be Good Science Mentors?
Shelby Bradford, PhD | Oct 1, 2024 | 3 min read
Two scientists weigh in on what makes for a successful mentorship experience.  
Image of female scientist crouching as she collects samples in a cave.
Spelunking for Microbes
Laura Tran, PhD | Oct 1, 2024 | 2 min read
Hazel Barton studies cave microbiomes and leverages their properties for unique applications.
Two male scientists working in a laboratory.
A Matter of Molecular Attraction
Mariella Bodemeier Loayza Careaga, PhD | Sep 16, 2024 | 2 min read
While studying the metabolism of the developing chick embryo, Marià Alemany Lamana’s team acted quickly to avert an error.
A brain section showing the mouse hippocampus. RNA molecules are shown in red.
Long Live the RNA
Mariella Bodemeier Loayza Careaga, PhD | Sep 16, 2024 | 2 min read
In the mouse brain, nuclear RNAs can last for years with some of them potentially helping to maintain genome integrity.
JFT1 has reacted with hydrogen peroxide and APEX2 to create red fluorescence near APEX2 that remains separate from the green mitochondria.
FLEXing a Bright New Idea
Shelby Bradford, PhD | Sep 16, 2024 | 1 min read
A modified fluorescent protein scheme survives harsh electron microscopy conditions, offering new solutions for dual imaging.
An illustration of neurons surrounded by protein aggregates.
Accelerating Protein Aggregation Analysis
The Scientist Staff | Sep 16, 2024 | 2 min read
Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases.
Researchers at the University of Arizona developed a pH-responsive probe that activated in the basic environment (purple) of the larval midgut and bound to gut proteins.
Gut-Powered Mosquito Probes
Laura Tran, PhD | Sep 16, 2024 | 2 min read
With the rise of insecticide resistance, researchers crafted a novel probe that selectively targets mosquito larvae’s weak spot.
Conceptual image of hands wearing surgical gloves holding a test tube filled with a liquid biopsy sample.
Enhanced Sequencing Results from Liquid Biopsies
The Scientist Staff | Sep 16, 2024 | 2 min read
Using a library preparation kit optimized for cell free DNA (cfDNA) provides high quality data for early cancer detection.
A computer monitor shows a video of two people sitting side by side singing and playing a guitar together.
The Soundtrack of Science
Laura Tran, PhD | Sep 16, 2024 | 2 min read
Barbara Di Ventura, a musician at heart and a scientist by trade, takes a musical approach to sharing research.
Researchers at the University of Arizona developed a pH-responsive probe that activated in the basic environment (purple) of the larval midgut and bound to gut proteins.
Science Crossword Puzzle
Stella Zawistowski | Sep 16, 2024 | 1 min read
Put on your thinking cap, and take on this fun challenge.
September 2024 crossword image
Nuts for Neuroscience
Stella Zawistowski | Sep 13, 2024 | 2 min read
Put on your thinking cap, and take on this fun challenge.
Image of an embryo built from Lego bricks showing cell populations in green and red.
Stem Cell-Based Embryo Models Add a Dimension to Developmental Biology
Shelby Bradford, PhD | Sep 13, 2024 | 10+ min read
Studying human embryonic development is complicated for several reasons. Models derived from pluripotent stem cells representing distinct stages offer a path to studying this process.
A microscopy image of various gold-colored diatoms.
Better Living Through Algae Biotechnology
Hannah Thomasy, PhD | Sep 13, 2024 | 10+ min read
Scientists explore how unicellular aquatic organisms could help humanity exist more sustainably.
Two neurons send electrical signals to each other.
Eavesdropping on Ion Channels Using the Patch Clamp Technique
Laura Tran, PhD | Sep 13, 2024 | 10+ min read
Cells send electrical impulses throughout the body, but electrophysiologists struggled to tune into these signals until the patch clamp technique was developed.
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