Magazine Issue

Historical samples of bloodstream infections hold secrets to Escherichia coli’s evolutionary history and the emergence of virulent clones.

Humans harbor both bacteria and viruses that help keep us healthy. Soon, they might cure us too.

Some elements of human immune systems serve important functions beyond fighting infections.

Annalise Rogalsky finally got the potassium metal to react, but not during her experiment.

Gene reactivation restored hearing after loss in mice, but the timing of intervention is key.

Science awards remind us that seemingly overnight success takes years of hard work and patience.

Diet-derived molecules spur a biological mechanism in the lung barriers of mice that prevents viral lung injury.

Population geneticist Tábita Hünemeier seeks out isolated indigenous groups living in the Brazilian Amazon rainforest to expand understanding of the human genome.

Put on your thinking cap, and take on this fun challenge.

Researchers can choose their own microplate adventure with these critical considerations for application setup.

Two autophagy genes work together to stop Mycobacterium tuberculosis dead in its tracks.

Digging into how and why some genes are resurrected after death sounds morbid, but it has practical applications. 

Researchers developed a novel protein fiber that tracks transcriptional events over time in living cells. This could shine a light on gene regulation during development or after cellular perturbations.

Bioinspired small molecules combat viral threats by targeting a common feature in enveloped viruses, making them useful against a wide range of viruses.

During development, neurons trim hundreds of excess axons in an intricately coordinated destructive process.

In the race to deliver successful gene therapies, frontrunner AAVs come head to head with underdog lipid nanoparticles. 

Advanced microscope systems enable researchers to perform high-resolution live-cell imaging, while maintaining cellular health.

As a group leader at the Broad Institute, Shantanu Singh develops tools to tackle high-dimensional biological data.

New innovations for reducing nonspecific fluorescence offer researchers clearer pictures and more multiplexing possibilities.