As first complimentary oligonucleotide is poised for market, questions remain about mechanisms |
Representatives of the drug's manufacturer, Isis Pharmaceuticals Inc. of Carlsbad, Calif., say fomivirsen (Vitravene) excels at binding to mRNA. However, some antisense researchers outside the company caution that, in the past, antisense molecules thought to be highly specific have latched onto other proteins. A U.S. Food and Drug Administration advisory committee, which recently recommended that the drug be approved for marketing, only weighs in on the safety and efficacy of the drug, not the mechanism by which it works.
If that mechanism is, indeed, truly antisense--that is, works primarily through a...
Interested in reading more?
Become a Member of
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!