G. Brown, J.J. Albers, L.D. Fisher, S.M. Schaefer, et al., "Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipopro-tein B," New England Journal of Medicine, 323:1289-98, 1990.

Greg Brown (University of Washington Medical Center, Seattle): "We have long known that cholesterol-loaded arteries in experimental animals will improve under conditions of low blood cholesterol; and clinical studies have been completed showing that reduction in cholesterol will result in an improvement in heart disease risk. Why, then, has it taken so long to show that cholesterol-lowering therapy can improve the diseased coronary arteries in such patients?

"First, an arterial disease measurement technique, such as the computer-assisted method developed in 1975 in our laboratory, was needed for objective analysis of atherosclerosis progression and regression. Second, more powerful diet and double drug combinations were found, which dramatically lowered LDL- and raised HDL-cholesterol. Third, we...

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