J.B. Stock, A.J. Ninfa, A.M. Stock, "Protein phosphorylation and regulation of adaptive responses in bacteria," Microbiological Reviews, 53:450-90, 1989.

Jeff Stock (Princeton University, Princeton, N.J.): "Although research on signal transduction has traditionally focused on eukaryotic cells, prokaryotes also respond to environmental signals. Recent studies, reviewed in this article, show that a single bacterial cell such as Escherichia coli may have as many as 50 different receptor kinases and comparable numbers of phosphorylated transcriptional regulators. The review has become a useful resource for microbiologists as a catalog of structure-function relationships that can be used to analyze newly sequenced bacterial signal transduction genes. It has also received widespread attention because some of the lessons learned from bacterial stimulus-response systems may be relevant to the more complex situations encountered in vertebrate organisms. "Signal transduction processes play important roles in areas including neurobiology, immunology, developmental biology, and oncology, and there is ample precedence in...

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