A new tool called PRISM draws on virus-host interactions and a DNA repair pathway to help researchers visualize how cellular stress may contribute to neurodegenerative disease.

The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore.

A technique that reversibly bundles tagged cargo into artificial membraneless compartments gives scientists the ability to switch cell processes on and off.

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.

Lab-grown cells from the reef-building coral Acropora tenuis provide new opportunities to study bleaching, symbioses, and biomineralization.

An automated wastewater monitoring technique could enable researchers to predict outbreaks of the virus up to a week in advance.

Researchers develop a caspase inhibitor that only works after being irradiated with UV light, giving them control over apoptosis in human cells.

A new inhibitor gives researchers the ability to control programmed cell death in cultured human T cells.

Testing out combinations of antiviral proteins from llamas could help researchers create potent virus-neutralizing multimers.

A novel preparation technique could facilitate vaccine preservation, transportation, and administration.

A novel sampler records data on a broad range of environmental contaminants.

A device for piercing individual holes in cell membranes allows vector-free DNA delivery while maintaining cell viability.

Modified gene editing machinery enables targeted disruptions of mitochondrial genes in rice and rapeseed plants.

Using reverse genetics, researchers create antibodies to reel in previously uncultured bacteria.

DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.

Recruiting an epigenetic instigator of centromere formation into large segments of cloned DNA facilitates their transformation into artificial chromosomes.

An implantable wireless device with microfluidic and optical components allows manipulation of individual nerve fibers in mice’s extremities.