D.W. Nebert, D.R. Nelson, M.J. Coon, R.W. Estabrook, et al., "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature," DNA and Cell Biology, 10:1-14, 1991.

Daniel W. Nebert (University of Cincinnati Medical Center): "This review is the third in a series of comprehensive, up- to-date compilations of data about members of the large cytochrome P450 gene superfamily. It serves to organize a large--and growing--body of sequencing and mapping data on 154 P450 genes. The nomenclature system, which groups more closely related genes, is based on the proposed divergent evolution of an ancestral gene that might have originated 3 billion years ago.

"Why is this paper being widely cited? A decade ago, the `cytochrome P450 field' encompassed redox [oxidation- reduction] enzymology and biochemistry, hemoprotein biophysics, and studies of steroidogenesis, drug metabolism, and metabolic activation of promutagens and procarcinogens. Up-regulation (induc- tion) of many P450 genes is known to...

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