Date: January 6, 1992, pp.16

H.-M. Jantzen, A. Admon, S.P. Bell, R. Tjian, "Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins," Nature, 344:830-36, 1990. (MOLECULAR BIOLOGY)

H.-Michael Jantzen (Howard Hughes Medical Institute, University of California, Berkeley): "During the past few years there has been tremendous progress in the identification of transcription factors that bind to specific promoter sequences of eukaryotic genes. However, little is known about the molecular mechanisms by which these proteins operate to regulate transcription initiation.

"We have isolated a gene encoding the human transcription factor hUBF [human upstream binding factor], which interacts with the essential factor SL1 to activate transcription of ribosomal RNA by RNA polymerase I in the nucleolus. hUBF is the first of a growing number of transcription factors that has a DNA-binding domain homologous to the chromosomal proteins HMG [high mobility group] 1 and 2, thus defining a new...

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