Date: January 6, 1992, pp.16

S.C. Hyde, P. Emsley, M.J. Hartshorn, M.M. Mimmack, et al., "Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance, and bacterial transport," Nature, 346:362-65, 1990. (MOLECULAR BIOLOGY) Christopher F. Higgins (Microbial Genetics Laboratory, Imperial Cancer Research Fund, University of Oxford, England):

"The ATP- binding cassette superfamily of transporters includes many biologically and clinically important proteins, such as the cystic fibrosis protein (CFTR), the human multidrug resistance protein (MDR), and the peptide transporter of the MHC complex.

"A highly conserved ATP-binding domain is diagnostic of this superfamily of proteins. We are therefore very interested in understanding the mechanisms by which this cassette couples the process of ATP hydrolysis to transport.

"Because the prospect of using crystallographic methods to determine the structure of the ATP-binding cassette is remote at present, we modeled the structure. This model provides a framework for designing experiments and for understanding...

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