C.V. Gunther, J.A. Nye, R.S. Bryner, B.J. Graves, "Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus," Genes & Development, 4:667-79, 1990.
Barbara J. Graves (University of Utah School of Medicine, Salt Lake City): "This paper reported our laboratory's serendipitous discovery that ets-1 encodes a sequence-specific DNA-binding protein. Our results implicated this proto-oncoprotein as a transcriptional regulator. Or findings, in conjunction with published information, had implications in three areas. First, our discovery provides a basis for proposing that ets-1-dependent cell transformation involves alterations in the gene expression of cells in erythroid and myeloid lineages. Second, the ets-1 protein had previously been shown to be phosphorylated in response to activation in T lymphocytes. A possible role for the ets-1 protein is as a transcription factor linking extracellular signals to gene regulation. Finally, the primary sequence of the...
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