L. Osborn, C. Hession, R. Tizard, C. Vassallo, et al., "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes," Cell, 59, 1203-11, 22 December 1989.

Laurelee Osborn (Biogen Inc., Cambridge, Mass.): "Vascular cell adhesion molecule 1 (VCAM1) is of interest to scientists in several disciplines, particularly those studying cell-cell adhesion mechanism and the mechanisms by which the inflammatory response begins and progresses. VCAM1 binds lymphocytes and monocytes and is induced by the inflammatory cytokines interleukin 1 and tumor necrosis factor a on the surface of endothelial cells. Therefore, VCAM1 has potential relevance to the normal operation of the immune response as well as to a large group of diseases in which vascular and other tissues are damaged by adhering and infiltrating mononuclear cells.

"This paper also describes a novel method of screening for cDNAs of adhesion molecules. This technique involves a direct...

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