Neurochemistry

Edited by Neeraja Sankaran

K. Basler, G. Struhl, "Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein," Nature, 368:208-14, 1994. (Cited in 50 publications through April 1995)

Comments by Gary Struhl, HowardHughes Medical Institute, Columbia University College of Physicians and Surgeons

Body-Building: Gary Struhl, top left, and Konrad Basler elucidated the role of the hedgehog protein in controlling limb development in fruit flies

This paper describes the role of a secreted signaling protein, called hedgehog (hh), during the development of the limbs of Drosophila. "Each limb of the fly is formed by two groups of cells, the anterior and posterior compartment. The hh protein is secreted by all the cells in the posterior compartment, and not at all by the anterior compartment cells," explains Gary Struhl, a Howard Hughes Medical Institute investigator and a professor of genetics and development at the Columbia University College of Physicians...