T. J. Coderre, R. Melzack, "The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury," Journal of Neuroscience, 12:3665-70, 1992.

Terence J. Coderre (Pain Mechanisms Laboratory, Clinical Research Institute of Montreal, Canada): "It has become increasingly evident over the past few years that, in addition to a sensitization of peripheral nociceptors, peripheral tissue injury leads to a sensitization of neurons in the central nervous system (CNS). This sensitization is a form of neuronal plasticity that may contribute to the development of persistent pain and hyperalgesia. It has also become evident that excitatory amino acids play a critical role in the development of various forms of neuronal plasticity, including long-term potentiation, neuronal growth, and neurotoxicity. Our studies were aimed at examining the potential involvement of an excitatory amino acid-dependent neuronal plasticity to the development of persistent pain following peripheral tissue injury.

"When injected subcutaneously...

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