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Millipore Announces Immobilon Sequencing Membranes Labconco Introduces WaterPro HPLC/UF Hybrid Polishing Station Multi-Channel Syringe Pipettes From Hamilton Jandel Releases Version 1.2 of SigmaScan/Image Software Corning Costar Corp. Unveils New Series of Microcentrifuges Molecular Probes' New Gram Stain Kit Spyglass Slicer For Volumetric Visualization National Biosciences Upgrades OLIGO Primer Analysis Software Waters Unveils HPLC System Perkin-Elmer Offers New Buffers For Capillary Electrophoresis Novocastra Offers p53 Antibodies DAKO Introduces New Conjugated Antibodies Nikon's Water-Immersion Microscope Objective Debuts CAChe Scientific Releases New Line of Chemistry Software Spire's MacSpec Software For Mass Spectral Analysis PerSeptive Offers Interferon Enzyme Immunoassay Kits Interlukin ELISA Kit from Genzyme pp.19,20 Millipore Announces Immobilon Sequencing Membranes Two new Immobilon membranes, both constructed of a polyvinylidene fluoride (PVDF) base, have been developed for specific western blotting and sequencing applications. The Immobilon-PSQ membrane reportedly has higher binding capacity than does standard PVDF, which ensures sample retention after microtransfer and subsequent processing. The membrane can be used for blotting and direct sequencing of small and rare proteins with automated sequencers. The Immobilon-CD membrane facilitates sequencing of N-terminally blocked proteins blotted to its surface. Its cationically derivatized matrix permits reversible immobilization of the sample so that blocked protein bands can be digested and eluted off the membrane surface for peptide mapping. Millipore Corp., Bedford, MA Circle No. 152 on Reader Service Card Labconco Introduces WaterPro HPLC/UF Hybrid Polishing Station The WaterPro PS polishing station is designed for diverse applications requiring both high-performance liquid chromatography-grade and pyrogen-free ultrafiltered water. Type I water is dispensed from a cabinet-mounted valve, and pyrogen-free water is delivered through a gun mounted on the dispensing station. The system uses carbon filtration, deionization, organic adsorption, and ultrafiltration water- purification technologies. The ultrafilter periodically flushes itself to maintain total organic carbon values of less than 10 parts per billion, and an ultraviolet reactor eliminates trace bacteria. Water is produced on demand; therefore, no storage tank is used. Labconco Corp., Kansas City, MO Circle No. 153 on Reader Service Card Multi-Channel Syringe Pipettes From Hamilton These four- and six-channel syringe pipettes are designed to transfer DNA samples by microplate row or column to sequencing gels, nylon membranes, or another microwell plate. These are offered in addition to the company's eight- and 12-channel syringe pipettes, so users may now transfer samples from 0.2 ul to 10 ul. Needle diameters are available for sample loading between 0.2 mm or thicker polyacrylamide gel casting plates, and for sample loading between 0.4 mm or thicker plates. Hamilton Co., Reno, NV Circle No. 154 on Reader Service Card Jandel Releases Version 1.2 Of SigmaScan/Image Software Version 1.2 of SigmaScan/Image for Windows measurement software includes more than a dozen new features for automating measurements from digitized photographs, charts, maps, blueprints, electrophoresis gels, microscope specimens, and other scientific and technical images. Among the new features available on the software upgrade are gray- level-based floodfill measurements, multiple-image splicing, image-annotation enhancements, and the Jandel Application Manager. In addition, the package enables users to save color and gray-level data for each pixel to and from the data worksheet. Jandel Scientific Software, San Rafael, CA Circle No. 155 on Reader Service Card Corning Costar Corp. Unveils New Series Of Microcentrifuges Researchers can choose from among three Costar 5Centrifuges: a fixed speed and two variable-speed models, with or without solenoid locking covers. The maximum speed of 10,000 rpm (5,600 x g) is suitable for separating DNA from agarose or acrylamide gels. Two rotors are supplied: a six-place for 1.5 and 2.2 ml tubes, and a 12-place for 0.6 ml tubes. Corning Costar Corp., Cambridge, MA Circle No. 156 on Reader Service Card Molecular Probes' New Gram Stain Kit Molecular Probes' LIVE BacLight Gram Stain Kit, a fluorescence-based assay, consists of two stains that, when applied to living bacterial cells, allow viable organisms to be analyzed quickly, without the need for fixing or washing cells. When stained with the two fluorescent dyes in this kit, gram-positive cells appear orange-red while gram- negative cells appear bright yellow-green. The LIVE BacLight Gram Stain is sensitive enough to analyze low numbers of bacteria in the presence of background material. The reagents can also be adapted for use with a fluorometer or a fluorescence microplate reader to quantitiate the relative proportion of gram-positive and gram-negative bacteria in a sample. Molecular Probes Inc., Eugene, OR Circle No. 182 on Reader Service Card Spyglass Slicer For Volumetric Visualization Spyglass Slicer, a volumetric data-analysis tool for Windows/Windows NT, reads a variety of data and image formats, including HDF (float and byte), netCDF, and binary and ASCII matrices. It also can convert stacks of 2D, HDF, binary, and ASCII data files as well as read HDF, Windows Bitmap, Targa, and TIFF image files. After the data are imported, the software uses ray tracing to render data as volumes, slices, or isosurfaces. Full control of alpha values makes it possible to make any object or data value transparent, translucent, or opaque for advanced volumetric rendering. Spyglass Inc., Savoy, IL Circle No. 157 on Reader Service Card National Biosciences Upgrades OLIGO Primer Analysis Software Version 5.0 of OLIGO Primer Analysis Software for Windows assists scientists in selecting the optimal oligonucleotides for the polymerase chain reaction (PCR), sequencing, hybridizations, and other applications. The new features include an oligonucleotide database for importing and exporting oligonucleotide sequences and data; a PCR primer search function to locate all cross-compatible primers; automatic degenerate primer selection from an amino acid sequence; hybridization time calculations; automatic searching for ligase chain reaction primers; batch searching for unique oligos in multiple files; and restriction enzyme searches. National Biosciences Inc., Plymouth, MN Circle No. 158 on Reader Service Card Waters Unveils HPLC System This high-performance liquid chromatography (HPLC) system with mass spectral compound detection capabilities contains a mass spectrometry detector in a user-oriented format that is designed to be simpler, more compact, and more economical than any mass spectrometers adapted for HPLC work. An interactive diskette is available that contains information on the following: system description; mass spectrometry; photodiode array detection; Millennium technology; and validation requirements. Waters, Milford, MA Circle No. 183 on Reader Service Card Perkin-Elmer Offers New Buffers For Capillary Electrophoresis Perkin-Elmer has introduced a selection of pre-made buffer solutions for capillary electrophoresis (CE) that are of high purity and meet stringent quality specifications. The selection of buffer solutions includes sodium phosphate at pH 2.5, sodium acetate at pH 4.0, sodium phosphate at pH 7.0, sodium borate/phosphate at pH 8.0, and sodium tetraborate at pH 9.0. The solutions come in 40-millimole concentrations, providing dilution flexibility for simplified methods development. Also available is a 200- millimole sodium dodecyl sulfate (SDS) solution for micellar electrokinetic capillary chromatography, for analysis of small, neutral compounds. Perkin-Elmer, Norwalk, CT Circle No. 184 on Reader Service Card Novocastra Offers p53 Antibodies Five clones of anti-human p53 antibody in unconjugated, biotinylated, and fluorescein-labeled form are available for use in immunohistochemistry, flow cytometry, and western blots. Also available are monoclonal and polyclonal antibodies to the MDM2 protein, reportedly the latest p53 binding protein to be discovered. Four anti-p53 clones are mouse monoclonals, and one is a rabbit polyclonal. Vector Laboratories is the exclusive United States distributor for Novocastra Laboratories. Vector Laboratories Inc., Burlingame, CA Circle No. 159 on Reader Service Card DAKO Introduces New Conjugated Antibodies The RPE-Cy5 fluorochrome-conjugated antibodies have been specifically optimized for flow cytometric applications, producing a sharp peak with an emission wavelength around 680 nm. The high fluorescence intensity of RPE-Cy5 conjugated antibodies is said to make them well suited for analyzing cell populations with low antigen expression. The company also offers CD3, CD4, CD8, CD13, and CD19 conjugated with this fluorochrome. DAKO Corp., Carpinteria, CA Circle No. 161 on Reader Service Card Nikon's Water-Immersion Microscope Objective Debuts The 60x water-immersion microscope objective is designed to resolve detail in living specimens at or close to the theoretical limit for optical performance at depths as great as 200 microns below the cover glass. The highly corrected 60x CFN Plan Achromat objective has a 1.2 numerical aperture and a 220-micron working distance. It has high transmission and chromatic correction for wavelengths in the near ultraviolet through the red spectrum, useful for confocal, fluorescence, and DIC microscopy. The lensU cover glass correction collar allows 0.15mm to 0.18 mm thick cover glasses to be used with critical correction. Nikon Inc., Instrument Group, Melville, NY Circle No. 162 on Reader Service Card CAChe Scientific Releases New Line Of Chemistry Software The company's new WorkSystem computer-aided chemistry software has been designed for the Apple Macintosh PowerPC desktop computer. The software features a stereoscopic three-dimensional graphics display and an intuitive user interface. It has a variety of applications for molecular modeling; prediction of chemical properties, structure, and reactivity; and experiment setup and documentation. CAChe Scientific Inc., Beaverton, OR Circle No. 163 on Reader Service Card Spire's MacSpec Software For Mass Spectral Analysis The software package enables users to extract and analyze information from gas chromatography mass spectrometry (GC- MS) data. With simple drawing tools, users can enter structures of up to 64 atoms or groups containing any element in the periodic table. Once entered, portions of the molecule may be "lassoed" to obtain formula and mass, at high or low resolution. Users may then build lists of formulas, calculate expected isotope patterns for each, and produce a simulated spectrum. Complex patterns with overlapping peaks may also be simplified. Spire Software, Maplewood, NJ Circle No. 160 on Reader Service Card PerSeptive Offers Interferon Enzyme Immunoassay Kits The new TiterZyme human interferon-g (IFN-g) and mouse IFN-g sandwich immunoassay kits are available for quantitative determination of human and mouse levels in serum or cell- culture supernatant. The kits feature detachable well strips, coated with the specific IFN-g antibody, for flexibility and consistency in simultaneous runs. These assays have sensitivities of less than 1 pg/ml in buffer and serum diluent. Each kit contains stable reagents for 96 tests, including a procedure with standard curves. PerSeptive Diagnostics Inc., Cambridge, MA Circle No. 164 on Reader Service Card Interleukin ELISA Kit From Genzyme The Predicta IL-1b ELISA kit facilitates rapid, sensitive, and specific measurement of IL-1b in human serum, plasma, and tissue-culture fluid specimens. The assay can measure IL-1b in a range from 3 to 256 pg/ml, and no measurable interference or cross-reactivity to IL-1 receptor antagonist is detected, according to the company. Each kit contains 96 precoated breakaway wells on a microtiter plate and the reagents needed to perform multiple runs. Genzyme Corp., Cambridge, MA Circle No. 165 on Reader Service Card

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