To the Editor:
In the article "Lab mouse genome isn't simple" by Cathy Holding, it is implied that the (not-so surprising) complex haplotype structure of the mouse genome will hinder the process of gene identification for quantitative traits. It simply isn't true.
The structure of genetic variation in the mouse, as elucidated by Yalcin et al. (
However, the most widely used methods of QTL analysis (Lander and Botstein,