Alzheimer’s-Related Protein Can Spread by Tainted Growth Hormone
Alzheimer’s-Related Protein Can Spread by Tainted Growth Hormone

Alzheimer’s-Related Protein Can Spread by Tainted Growth Hormone

A hormone treatment contaminated with amyloid-β given to mice caused the protein’s accumulation in their brains, suggesting the same could have occurred in humans given the therapy.

Carolyn Wilke
Dec 14, 2018

ABOVE: Illustration of amyloid plaque
© ISTOCK.COM, SELVANEGRA

Researchers injected mouse brains with a growth hormone tainted with amyloid-β, a protein implicated in Alzheimer’s disease, and saw it accumulate. The study, published yesterday (December 13) in Nature, bolsters the hypothesis that amyloid-β may be spread from one person to another under rare conditions from contamination, but does not show the protein to be contagious.

The idea that the protein could be transferred between people gained traction after a 2015 study found unusually large deposits of amyloid-β in the autopsied brains of four people who had received injections of growth hormone as children in the United Kingdom. Thousands of children received growth hormone derived from cadavers to treat stunted growth between 1958 and 1985, The Guardian reports.

The new study confirms that some growth hormone back then was contaminated with amyloid-β. The researchers then injected the contaminated hormone...

Synthetic growth hormone has since replaced that derived from cadavers. But to prevent this sort of spread in the future, The Guardian reports, surgeons should decontaminate tools used for brain surgery more thoroughly.

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