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Artificial Mouse Embryo Made in a Laboratory

The embryo, grown in a dish from several types of stem cells, went through gastrulation, a significant stage in development.

Jul 25, 2018
Sukanya Charuchandra

ABOVE: Synthetic embryo-like structure made of three stem cell types in yellow, pink, and green
ZERNICKA-GOETZ LAB, UNIVERSITY OF CAMBRIDGE

Researchers have used three types of stem cells to create a mouse embryo in a dish, according to research published in Nature Cell Biology yesterday (July 23). The cultured embryos transformed into a multilayered structure, which helps establish subsequent cell types and axes of the body. When the mixture of cells attained the appropriate density, they independently self-organized into a clump. 

“Our artificial embryos underwent the most important event in life in the culture dish,” coauthor Magdalena Zernicka-Goetz, a professor at the University of Cambridge in the U.K., says in a statement. “They are now extremely close to real embryos.” For further growth, the artificial embryos would need to be implanted into a real or synthetic womb.  

Using their lab-made embryo, the researchers can better understand how the three types of stem cells affect each other and probe the intricacies of development. 

“While [this study] did not use human stem cells, it is not too far-fetched to think the technique could one day be applied to studying early human embryos,” Christophe Galichet, a senior research scientist at the Francis Crick Institute in the U.K. who was not involved in the study, writes to Reuters.

July 2019

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