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Fecal Transplants More Successful from “Super-Donors”

Fecal Transplants More Successful from “Super-Donors”

A review finds that for several conditions, poop from certain healthy people is more likely to provide relief for recipients.

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Shawna Williams

Shawna joined The Scientist in 2017 and is now a senior editor and news director. She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the University of California, Santa Cruz.

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Jan 22, 2019

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Not all poop is equally valuable, at least when it comes to fecal transplants. Some people, it appears, generate waste that is better at alleviating conditions associated with gut microbiome imbalances than others, according to a review article published yesterday (January 21) in Frontiers in Cellular and Infection Microbiology.

“Strategies to find super-donors whose stool is especially effective as a curative are still in their infancy, although progress on this topic—or making synthetic super-donors from the stool of many people—could greatly improve application of [faecal transplants],” Rob Knight, a microbiology researcher at the University of California, San Diego, who wasn’t involved in the review, tells The Guardian

The authors of the paper looked at studies on the use of fecal microbiota transplants (FMT) to treat Clostridium difficile infection, inflammatory bowel disease, constipation, allergic colitis, and other conditions. They write in their conclusion that...

The review follows another study on fecal transplants published earlier this month (January 15), in which researchers tested the therapy for ulcerative colitis. Of subjects who received three transplants over seven days from donors, 32 percent were in remission eight weeks later, compared with just 9 percent of patients who received control treatments with their own stool, the authors report. 

Coauthor Sam Costello of the Queen Elizabeth Hospital in Adelaide, Australia, says in a statement that an important difference between this and previous studies was that the stool samples were processed anaerobically. “Many gut bacteria die with exposure to oxygen and we know that with anaerobic stool processing a large number of donor bacteria survive so that they can be administered to the patient,” Costello explains. “We believe that this may be the reason that we had a good therapeutic effect with only a small number of treatments.”

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Fecal Transplants More Successful from “Super-Donors”

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