Mapping the Neighborhoods of the Gut Microbiome

Researchers are going beyond fecal samples to understand how the patterns of commensal microbes in the gastrointestinal tract influence development and health.

Written byAbby Olena, PhD
| 7 min read
An image of part of a mouse distal colon showing luminal contents with bacteria in magenta, the mucus lining (green) and the epithelial cell barrier of the gut (blue, right).
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Dissecting wombats’ intestines isn’t the easiest way to get an idea about what’s happening with their gut microbiomes, yet that’s what University of Adelaide postdoc Raphael Eisenhofer and his colleagues did for a recent study. Collecting poop would have been easier—particularly for endangered species like wombats—but the researchers wanted more information than they could glean from a stool sample.

“We’ve been using feces for quite a long time now because they’re very easy to get, but what we know about microbial ecology is it’s all about location—where the microbes are in the interface of the host,” Eisenhofer explains.

He and his coauthors characterized the microbial biogeography, or the spatial information about what microbes are present where, of the gastrointestinal (GI) tracts of one bare-nosed wombat (Vombatus ursinus) and one southern hairy-nosed wombat (Lasiorhinus latifrons). Eisenhofer acknowledges the limitations of using just two wombats, yet the team still found some surprises.

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Meet the Author

  • abby olena

    As a freelancer for The Scientist, Abby reports on new developments in life science for the website. She has a PhD from Vanderbilt University and got her start in science journalism as the Chicago Tribune’s AAAS Mass Media Fellow in 2013. Following a stint as an intern for The Scientist, Abby was a postdoc in science communication at Duke University, where she developed and taught courses to help scientists share their research. In addition to her work as a science journalist, she leads science writing and communication workshops and co-produces a conversational podcast. She is based in Alabama.  

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