Menu

Researchers Create Hair-Growing Skin Organoids

The mini-organs reproduce the two cell layers present in mouse skin and the development of hair follicles, providing a potential model for skin and hair research.

Jan 2, 2018
Catherine Offord

A spherical skin organoid showing the generation of multiple cell layers.EUREKALERT, JIYOON LEE AND KARL R. KOEHLER

Researchers at Indiana University have developed the most realistic mouse skin tissue to be grown in a lab to date, according to a study published yesterday (January 2) in Cell Reports. The new mini-organs, or organoids, grow in 3-D culture and produce hair follicles, making them potential models for research into skin development, skin diseases, and hair growth.

To develop the organoids, the Indiana team cultured pluripotent stem cells from mouse skin. Unlike previous approaches, which have generally grown different layers of the skin separately and then combined them later, the researchers grew the stem cells in a specially developed 3-D medium, resulting in the simultaneous development of both the upper and lower layers of skin in a growing ball of cells suspended in culture.

“You can see the organoids with your naked eye,” study coauthor Karl Koehler of the Indiana University School of Medicine says in a statement. “The skin develops as a spherical cyst, and then the hair follicles grow outward in all directions, like dandelion seeds.”

In the process of the research, the team discovered that the early development of this cyst was crucial to later hair follicle development—disrupting the initial organization of dermal cells blocked follicle growth, Koehler says in the press release. “We think that it’s very important that the cells develop together at an early stage to properly form skin and hair follicles.”

The researchers are now hoping to develop a similar model with human cells, which, Koehler says in the statement, “could be potentially a superior model for testing drugs, or looking at things like the development of skin cancers, within an environment that’s more representative of the in vivo microenvironment.” 

September 2018

The Muscle Issue

The dynamic tissue reveals its secrets

Marketplace

Sponsored Product Updates

Enabling Genomics-Guided Precision Medicine

Enabling Genomics-Guided Precision Medicine

Download this eBook from Qiagen to learn more about the promise of precision medicine and how QCITM Interpret can help deliver better care with better knowledge.

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Best Practices for Sample Preparation and Lipid Extraction from Various Samples

Download this white paper from Bertin Technologies to learn how to extract and analyze lipid samples from various models!

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.

Immunophenotypic Analysis of Human Blood Leukocyte Subsets

Immunophenotypic Analysis of Human Blood Leukocyte Subsets

Download this application note from ACEA Biosciences, Inc., to find out how to perform an immunophenotypic analysis of a human blood sample utilizing 13 fluorescent markers using a compact benchtop flow cytometer equipped with 3 lasers!