Study: Vaping Causes DNA Damage in Human Cells and Mice
Study: Vaping Causes DNA Damage in Human Cells and Mice

Study: Vaping Causes DNA Damage in Human Cells and Mice

New findings suggest that nicotine inhaled from e-cigarettes could contribute to cancer and heart disease, but critics warn that the data are too preliminary to draw such conclusions.

Ashley Yeager
Jan 30, 2018


Nicotine inhaled from e-cigarettes can damage DNA in mouse heart, lung, and bladder and in cultured human lung and bladder cells, a new study shows. The results, published Monday (January 29) in PNAS, suggest that vaping increases the risk of developing cancer and heart disease and reinforce the research showing e-cigarettes’ risks to human health.

The DNA changes were similar to those linked to secondhand smoke, study coauthor Moon-shong Tang of New York University tells The Guardian. Specifically, the team found that two mutagenic compounds develop in lung, bladder, and heart cells exposed to e-cigarette smoke. DNA-repair activity and the repair proteins XPC and OGG1/2 were reduced in the lung tissue of mice.

See “Swapping Cigarettes for Vaping

Critics caution that the mice in the study were exposed to higher levels of e-cigarette smoke than those who vape might inhale...

In the paper, Tang and his colleagues concede that “it takes decades for carcinogen exposure to induce cancer in humans, [so] for decades to come there will be no meaningful epidemiological study to address the carcinogenicity of [e-cigarette smoke].” Still, the levels of carcinogenic compounds are higher in the blood of vapers than nonsmokers, pointing to the increased risk of developing cancer.

The bottom line, Tang tells Bloomberg, is: “Don’t think a vapor is harmless.”