WIKIMEDIA COMMONS, PEIR DIGITAL LIBRARY
A chromatin-regulation protein controls the epigenetic reprogramming that drives acute myeloid leukemia (AML). Knockdown of this protein, which normally upregulates the oncogene Myc, selectively killed the AML cells, and suggests a new target for treating this aggressive disease.
Inflammasomes activate innate immune inflammation, but how these proteins were activated was poorly understood. Now researchers discover a family of proteins called NAIPs, previously thought to play a non-essential role, which act as sensors that specifically detect several bacterial components and activate the inflammasome.
Although the role of the Wnt family of proteins in development is well established, its control of blood cell development has been controversial. Now researchers show that different blood cell lineages are generated by varying the level of Wnt.
Using genetic bar-coding and high throughput sequencing, researchers used far fewer mice to track blood stem cells as they differentiate into various blood cell types, demonstrating that each stem cell does not contribute to all of the lineages equally.
Researchers find a subset of dendritic cells (DC)—antigen-presenting cells—that circulate in the lungs, engulf apoptotic cells, and travel to the lymph nodes to present their cargo. If these DCs activate anti-tumor immunity, it could have implications for lung-cancer immunotherapy.
Cohesin, a molecule involved in separating sister chromatids during cell division, surprisingly, appears to play a role during T-cell receptor rearrangement—a process that gives the T-cells their extensive pathogen-detecting repertoire.
The F1000 Top 7 is a snapshot of the highest ranked articles from a 14-day period on Faculty of 1000 Immunology, as calculated on October 14, 2011. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com.