Ron Magold
Medical Products Department
E.I. du Pont de Nemours & Co.
Wilmington, Del.

" Modifications in cyclopropyl iminium ion rearrangements have led to the new synthetically versatile methodology. Total synthesis of (+)-Lycorine has been used to exemplify this elegant method.

R.K. Boeckman, S.W. Goldstein, M.A. Walters, "Synthetic studies of the cyclopropyl iminium ion rearrangement. Part 3. Application of the cyclopropyl acyliminium ion rearrangement to a concise and highly convergent synthesis of (+)-Lycorine," Journal of the American Chemical Society, 110 (24), 8250-2, 23 November 1988.

" The inhibition of the HIV-1 proteinase is widely recognized as a potential therapeutic target for AIDS treatment. Research has been thwarted by lack of effective assays. A recent paper describes peptide reagents as substrates and inhibitors of the HIV-1 proteinase that may assist the discovery of therapeutic agents for AIDS.

S. Billich, M.-T. Knoop, J. Hansen, P. Strop, et al., "Synthetic peptides as substrates...

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