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Author: SIMON SILVER
Department of Microbiology & Immunology
University of Illinois
- Ubiquitin (an abundant 76-amino-acid polypeptide responsible for protein turnover in eukaryotes) requires covalent attachment to target proteins to guide proteolysis. Two new heat-shock genes for ubiquitin-conjugating (UBC) enzymes have been identified, cloned, and sequenced in yeast. The products are needed for protein turnover. Previously identified UBC genes affect diverse cellular processes, including DNA repair, sporulation, and G1...