Steps in positional cloning. Positioning of disease loci to chromosomal regions requires multidisciplinary collaborations.
Green goes on to point out that this is a classic example of finding a gene from sequences the Human Genome Project is posting on the World Wide Web every night (www.nhgri.nih.gov/Data/#mapping). Other groups trying to find PDS were looking at the Washington University sequence as well.3 "It was a horse race. We competed to the end," says Green.
Going Beyond the GeneOnce researchers located PDS, they used the sequence of nucleotides to identify a protein the scientists named pendrin. A computer search found the amino acid sequence of pendrin is...
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