NIMH shifts research priorities

Psychologists funded by the US government, already wary of congressional meddling in peer-reviewed federal research grants, say they are now concerned that the National Institute of Mental Health (NIMH), their primary source of federal support, is curtailing funding for social and behavioral sciences, areas traditionally considered integral to basic research in the field.Under a strategic reorganization plan that takes effect tomorrow (October 1), NIMH, one of the 27 institutes and centers of the National Institutes of Health (NIH), will shift research funding to areas deemed to have the most relevance to public health issues, such as neurological diseases and major mental disorders. "We have a mission from Congress to focus on mental health," NIMH Director Thomas Insel told The Scientist. "There are areas we are trying to redirect, areas we need to look at more closely."Officials at professional research societies say that starting about 6 months ago, NIMH began rejecting far more grant applications from behavioral and social scientists than ever before. "They would get a note saying, 'Sorry, this is no longer relevant to the mission of NIMH,'" said Steve Breckler, executive director for science at the American Psychological Association. "It's causing alarm bells to go off." "I'm hearing from a lot of scientists who have been affected by this," said Barbara Wanchisen, executive director of the Federation of Behavioral, Psychological, and Cognitive Sciences. "It's pretty clear that unless the research has some kind of neuroscience or physiological bent to it, it's probably not going to be heavily favored for funding." But Insel denied any bias against basic behavioral, social science, or anthropological research. "We feel a need for the best cognitive science and the best behavioral science to address the public health issues in front of us, which is mental illness," he said. "But if we already have had 10 people doing some work, we would want to save that money for an area where we don't have anything yet."Part of the problem, Insel said, is that some research psychologists have come to expect their grants to be renewed or extended multiple times. "There is often a sense in the academic community that they think of NIMH as a source of support, whereas we look at the academic community as a source of answers," he said. "We are looking for areas where people can complete a study and go on—not just add a brick to the wall, but start a new wall and finish it."NIMH is the government's largest funding agency for mental health research, supporting more than 3000 research project grants with a $1.4 billion budget for fiscal year 2004. But after 5 years of major budget increases, NIMH is now facing fiscal constraints: higher grant costs, smaller budget increases, and a larger pool of grant applicants. To address these issues, Insel last year assembled a 23-member advisory committee to review research priorities. The committee's report, issued in May, recommended giving highest funding priority to "understanding the potential causes, treatment, and prevention of mental illness and behavioral disorder." Grants having greater relevance to translational research should take precedence over those that focus on "well established phenomena, paradigms, and methods," the report states. NIMH grants must now demonstrate "relevance, traction, and innovation," Insel said, meaning that they should make practical contributions to mental health in new ways, and do so expeditiously. Because of this change, some psychologists complain, proposals in areas that NIMH had previously funded are now being sent back unreviewed. Others have been advised to submit their proposals to other NIH institutes or even to the National Science Foundation, the government's next-largest funder of social science and behavioral research.Robert Goldstone, a psychology professor at Indiana University in Bloomington, said he received notice from NIMH 2 weeks ago that his proposal to study group behavior in decision making was not recommended for peer review because it wasn't pertinent to mental health issues. "It would have had relevance to many different health applications," said Goldstone, who has held several NIMH grants to study perceptual and conceptual learning since 1999. "At least it should have been reviewed for merit." In other cases, Insel has overturned or substantially reduced funding levels for research grants that had scored well in peer-review study sections and had been recommended for funding by NIMH's National Advisory Mental Health Council. Robert Seyfarth, a psychology professor at the University of Pennsylvania, was told in February that his grant renewal application to study the social behavior of primates had been recommended for funding by both the study section and advisory council. But he later learned that Insel had overturned the recommendations because the project was not related to a specific disease. "This hit us just at a time when we were moving from basic research on social behavior to research that links social behavior and stress, said Seyfarth, who has received 16 NIH grants and renewals since 1978. "It was surprising to us that we were singled out for no approval just when our work was moving toward this new direction." After further discussions, he said, Insel agreed to fund Seyfarth's research, but at a much-reduced level and for fewer years.Insel explains that very few grants were paid the full requested amount this past year, regardless of subject area. "We have been reducing budgets by 10% [on average] to allow us to stretch the dollars in each cycle to pay more grants. Some projects are being reduced considerably more to allow full payment of a few high-priority grants or to permit us to stretch the budget to include a new investigator," he wrote in an E-mail reply to questions from The Scientist.Insel did not deny that he had overturned funding recommendations. "Have I nixed grants that were very high scoring [in the top 10th percentile]? This would be a very rare event—generally this occurs when council votes for low program priority," he wrote. "But institute directors ultimately make the decision about what to pay with each budget cycle—managing the portfolio is the core of an institute director's job."

NIMH shifts research priorities

Scientists fear curtailed funding for basic social and behavioral research

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