Z. Mourelatos et al., "miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs," Genes & Development, 16[6]:720-8, March 15, 2002.

"A novel ribonucleoprotein (RNP) complex in HeLa cells was identified that contains two proteins implicated in spinal muscular atrophy (SMA), eIF2C2 (a member of the Argonaute family), and numerous small RNAs ~22 nucleotides in length. The finding that microRNAs (miRNAs) associate with eIF2C2 ties together genetic findings demonstrating that Argonaute family members are required for maturation of small temporal RNAs and short interfering RNAs, and that Argonaute 2 is a component of RISC (RNA induced silencing complex), essential for RNA interference. The finding that one of SMA proteins is a DEAD-box RNA helicase suggests it may be involved in RNA unwinding or RNA restructuring events. Overall, this paper provides new information about miRNAs, the proteins they associate with, and their possible connection to a devastating neurodegenerative disease."

—Marjori Matzke,...

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?