J.S. Andersen et al., "Directed proteomic analysis of the human nucleolus," Current Biology, 12:1-11, Jan. 8, 2002.

F1000 Recommendation: Must Read

"This is a good paper showing the large scale analysis of a very large protein complex, the nucleolus. [Points of interest]: The size of the complex and that it is dynamic. The mass spectrometry methods used here were a combination of high throughput (matrix-assisted laser desorption ionization coupled to time of flight detection) and low throughput (static nanoelectrospray). Both were apparently needed to achieve the 271 protein total that was reported."
—Steven Gygi,
Harvard Medical School, US

Molecular Medicine

W.K. Scott et al., "Complete genomic screen in Parkinson disease: Evidence for multiple genes," Journal of the American Medical Association, 286:2239-44, Nov. 14, 2001.

F1000 Recommendation: Must Read

"I think this is an interesting, but flawed study, suggesting that tau is locus for Parkinson's...

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