T.J. Macke et al., "RNAMotif, an RNA secondary structure definition and search algorithm," Nucleic Acids Research, 29:4724-35, Nov. 15, 2001.

F1000 Recommendation: Recommended

"This paper describes a new computer program that allows searching of genomic sequence databases for complex RNA structural elements. RNAMotif represents a major technical advance over previously available tools in that it allows the user to specify multiple parameters, including non-canonical base-pairings and variability in spacing, and to assign scoring values to each parameter. Several examples of search descriptors and the results of the search are included to demonstrate the utility of the algorithm."
—Tina Henkin,
Ohio State University, US

RNA Stability

S.M. Elbashir et al., "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate," EMBO Journal, 20:6877-88, Dec. 3, 2001.

F1000 Recommendation: Must Read

"Elbashir et al. get down to the hard work of dissecting how...

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!