One-Shot COVID-19 Vaccine Prevents Severe Disease

Johnson & Johnson’s vaccine is less effective at preventing COVID-19 than other approved vaccines are, but experts say it could still be an important tool in curbing the pandemic.

Written byAsher Jones
| 2 min read
SARS-CoV-2, COVID-19, coronavirus, pandemic, virus, vaccine, vaccination, outbreak, infectious disease, Johnson & Johnson, Moderna, Pfizer, drug development

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

ABOVE: © ISTOCK.COM,
BLUECINEMA

Johnson & Johnson announced today (January 29) that its one-shot vaccine is 66 percent effective at preventing moderate and severe COVID-19 and 85 percent protective against severe disease.

“This is a really great result,” Akiko Iwasaki, an immunologist at Yale University, tells The New York Times. “I hope this vaccine gets approved as soon as possible to reduce disease burden around the world.”

No one who received the shot died of COVID-19, while five individuals in the placebo group did, Reuters reports. “The key is not only overall efficacy but specifically efficacy against severe disease, hospitalization, and death,” Walid Gellad, a physician who studies health policy at the University of Pittsburgh, tells Reuters.

Although the company’s vaccine is less effective at preventing COVID-19 than Moderna’s and Pfizer’s versions are, it still surpasses the US Food and Drug Administration’s 50 percent efficacy requirement for emergency use approval. Unlike ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies