One-Shot COVID-19 Vaccine Prevents Severe Disease

Johnson & Johnson’s vaccine is less effective at preventing COVID-19 than other approved vaccines are, but experts say it could still be an important tool in curbing the pandemic.

Written byAsher Jones
| 2 min read
SARS-CoV-2, COVID-19, coronavirus, pandemic, virus, vaccine, vaccination, outbreak, infectious disease, Johnson & Johnson, Moderna, Pfizer, drug development

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

ABOVE: © ISTOCK.COM,
BLUECINEMA

Johnson & Johnson announced today (January 29) that its one-shot vaccine is 66 percent effective at preventing moderate and severe COVID-19 and 85 percent protective against severe disease.

“This is a really great result,” Akiko Iwasaki, an immunologist at Yale University, tells The New York Times. “I hope this vaccine gets approved as soon as possible to reduce disease burden around the world.”

No one who received the shot died of COVID-19, while five individuals in the placebo group did, Reuters reports. “The key is not only overall efficacy but specifically efficacy against severe disease, hospitalization, and death,” Walid Gellad, a physician who studies health policy at the University of Pittsburgh, tells Reuters.

Although the company’s vaccine is less effective at preventing COVID-19 than Moderna’s and Pfizer’s versions are, it still surpasses the US Food and Drug Administration’s 50 percent efficacy requirement for emergency use approval. Unlike ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Share
Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.
June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

View this Issue
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo
Unraveling Complex Biology with Advanced Multiomics Technology

Unraveling Complex Biology with Five-Dimensional Multiomics

Element Bioscience Logo
Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Twist Bio 
The Scientist Placeholder Image

Seeing and Sorting with Confidence

BD

Products

The Scientist Placeholder Image

Waters Enhances Alliance iS HPLC System Software, Setting a New Standard for End-to-End Traceability and Data Integrity 

The Scientist Placeholder Image

Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

agilent-logo

Agilent Announces the Enhanced 8850 Gas Chromatograph

parse-biosciences-logo

Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies