CHEMISTRY
BY RON MAGOLDA
Medical Products Department
E.I. DuPont de Nemours & Co
Wilmington, Del
" A recent paper proposes DNA recombination to proceed via branched DNA molecules. The researchers used site-specific probes to understand the interactions.
Q. Guo, N.C. Seeman, N.R. Kallenbach, “Site-specific interaction of intercalating drugs with a branched DNA molecule,”Biochemistry, 28, 2355-9, 21 March 1989. (New York University, New York)
A structural analysis of the interaction of different alpha-helices with ions resulted in the discovery of very similar alpha-helix motifs orientation.
J.S. Richardson, D.C. Richardson, “Helix lap-joints as ion-bind- ing sites: DNA-binding motifs and Ca-binding ‘EF Hands’ are related by charge and sequence reversal,” Proteins: Structure, Function, and Genetics, 4(4), 229-39, 1989 (Duke University, Durham, N.C.)
Characterization and substrate specificity studies on the recombinant HIV-l protease has produced an important finding in a rapidly growing area of research.
T.D. Meek, RD. Dayton,...
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