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The EtiologyARTICLE EXTRASMolecular MysteriesGazing DownstreamSeeing SchizophreniaNeurotrailblazerPregnancy, Chromosomes, and ReceptorsAlthough science has made significant strides in the understanding of schizophrenia, in many ways its causes remain as mysterious today as they were when Eugen Bleuler coined the term in 1905. As Melinda Wenner describes in this section, the dopamine hypothesis that gave rise to a generation of antipsychotics has been forced to share the stage with a host of othe
The Disease ARTICLE EXTRAS Living with Schizophrenia Robin Cunningham Marianne Emanuel A Very Expensive Disease Schizophrenia in Childhood This year, some 600,000 people will be diagnosed with schizophrenia. That's 600,000 lives - and many times that when you consider their families - thrown into what some have described as a living hell. People with the disease are far more likely to be jobless, ill with other diseases, and commit suicide. So it is approp
The Treatments ARTICLE EXTRAS A Troubled History First-Generation Antipsychotic Drugs The Atypical Atypical? The next generation? The Lessons of CATIE Second-Generation Antipsychotic Drugs Beyond Drugs Nonmedication Therapies When you add up the direct costs of treating patients with schizophrenia, it is a staggering number: $22 billion in the United States alone. As effective as many of them are, antipsychotic drugs are costly, and many have signific
A Troubled History Antipsychotics are effective, but carry significant side effects and cost. What's on the horizon? ARTICLE EXTRAS The Treatments First-Generation Antipsychotic Drugs The Atypical Atypical? The next generation? The Lessons of CATIE Second-Generation Antipsychotic Drugs Beyond Drugs Nonmedication Therapies Soon after antipsychotics entered the market in the 1950s, policymakers were so impressed with their benefits th
The next generation? ARTICLE EXTRAS The Treatments A Troubled History First-Generation Antipsychotic Drugs The Atypical Atypical? The Lessons of CATIE Second-Generation Antipsychotic Drugs Beyond Drugs Nonmedication Therapies This table lists a selection of antipsychotics in the pipeline. For a story on a new class of drugs some are referring to as the "atypical atypicals," click here. For a table of first-generation drugs, click here. For a table of a
Second-Generation Antipsychotic Drugs This table lists the atypical antipsychotics. For a story on the lessons of the CATIE trial, click here. For a table of first-generation drugs, click here. For a table of drugs in the pipeline, click here. Drug Brand name(Manufacturer) Approval date Indications Mechanism Cost per 30-day supply* Contraindications/Adverse reactions Injection availability Other data Clozapine Clozaril (N
Survey Methodology Related Articles Best Places to Work in Academia, 2007 Easy livin' at Dalhousie First-Timers Massachusetts General Hospital: View from the top Purdue pushes forward Ranking Tables Top 15 US Academic Institutions Top 10 International Academic Institutions Top 40 US Academic Institutions Best Countries for Academic Research Best Places to Work: Survey Findings PDF Survey Form: A web
The RNA Conductome What can we learn from the in-process encyclopedia of how non-protein-coding sequences exert genetic control? The Scientist Staff Over the years, scientists and drug companies seeking genetic control over biological systems have focused their attention on proteins. But that's only one part of the picture: Recently, scientists have been accumulating evidence that non-protein-coding sequences often play the role of conductor in the body's response: it'
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