M.N. Alder et al., "Diversity and function of adaptive immune receptors in a jawless vertebrate," Science, 310:1970-3, Dec. 23, 2005.

A computational analysis indicates that agnathans [jawless fishes] have the potential to generate from 1014 to 1017 different variable lymphocyte receptor (VLR) genes through a process of somatic rearrangement, a level of diversity comparable to that of mammalian antibodies.

John Jaenike
University of Rochester, NY

N.M. Alto et al., "Identification of a bacterial type III Effector family with G protein mimicry functions," Cell, 124:133-45, Jan 13 2006.

This study reports that type III effectors sharing a WxxxE motif act as Rho GTPase functional mimics. Although none of these effectors show sequence homology with GTPases, the EPEC Map protein induces Cdc42-like actin rearrangements, whereas the Shigella IpgB1 and IpgB2 effectors act as the Rac and the Rho GTPases, respectively.

Guy Tran Van Nhieu
Institut Pasteur, France

F.J. AdriÁn et...

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