J.C. Hermann et al., "Structure-based activity prediction for an enzyme of unknown function," Nature, 448:775-9, Aug. 16, 2007.
The X-ray crystallographic structure of the gene product Tm0936 from the amidohydrolase superfamily, deposited by a structural genomics consortium, was used to dock, score, and sort a library of 22,500 high-energy intermediates as ligands, leading to the successful prediction that the enzyme acts as an S-adenosylhomocysteine deaminase.
Boston University School of Medicine, United States
C.V. Carman et al., "Transcellular diapedesis is initiated by invasive podosomes," Immunity, 26:784-97, June 2007.
The authors ... show that leukocytes use a protrusive type of podosome to probe the surface of the underlying endothelial cell, and eventually to push organelles out of the way as the leukocytes migrate through.
University of North Carolina, Chapel Hill, United States
S.M. Kaiser et al., "Restriction of...