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Upon infection of its host, human cytomegalovirus (HCMV) expresses a miRNA that directly down-regulates expression of an immunorelated gene, MICB. Thus, it appears that HCMV has developed two distinct mechanisms to down-regulate expression of the same immunorelated gene, with the RNA-based strategy presumably being more ancient.
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In the absence of MyD88, APCMin/+ mice are less susceptible to developing intestinal cancers. Interestingly, MyD88 signaling does not influence the formation of early neoplastic lesions but is involved in tumor growth and progression.
European Institute of Oncology, Italy
J.L. Rinn, et al., "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs," Cell...