Papers to Watch

N. Stern-Ginossar, et al., "Host immune system gene targeting by a viral miRNA." Science, 317:376-81, July 20, 2007. Upon infection of its host, human cytomegalovirus (HCMV) expresses a miRNA that directly down-regulates expression of an immunorelated gene, MICB. Thus, it appears that HCMV has developed two distinct mechanisms to down-regulate expression of the same immunorelated gene, with the RNA-based strategy presumably being more ancient. -

The Scientist Staff
Oct 1, 2007

N. Stern-Ginossar, et al., "Host immune system gene targeting by a viral miRNA." Science, 317:376-81, July 20, 2007.

Upon infection of its host, human cytomegalovirus (HCMV) expresses a miRNA that directly down-regulates expression of an immunorelated gene, MICB. Thus, it appears that HCMV has developed two distinct mechanisms to down-regulate expression of the same immunorelated gene, with the RNA-based strategy presumably being more ancient.

--Sabine Müller
Ernst-Moritz-Arndt-Universität, Germany

S. Rakoff-Nahoum, et al., "Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88," Science, 317:124-7, July 6, 2007.

In the absence of MyD88, APCMin/+ mice are less susceptible to developing intestinal cancers. Interestingly, MyD88 signaling does not influence the formation of early neoplastic lesions but is involved in tumor growth and progression.

--Maria Rescigno
European Institute of Oncology, Italy

J.L. Rinn, et al., "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs," Cell...